C73 NEW MECHANISMS AND THERAPIES IN COPD: Increased Platelet-Monocyte Interaction In Stable COPD In Absence Of Platelet Hyper-Reactivity

Platelet activation status was determined using flow cytometry by measuring the binding of fibrinogen to the activated fibrinogen receptor (aIIbß3) and the expression of P-selectin (CD62P). Platelet reactivity was measured by expression of these markers after stimulation with the platelet agonists a...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Aleva, F, Temba, G, De Mast, Q, Simons, S, De Groot, P, Heijdra, Y, Van Der Ven, A
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Flow cytometry
Online Access:Get full text
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Summary:Platelet activation status was determined using flow cytometry by measuring the binding of fibrinogen to the activated fibrinogen receptor (aIIbß3) and the expression of P-selectin (CD62P). Platelet reactivity was measured by expression of these markers after stimulation with the platelet agonists adenosine 5' diphosphate (ADP), collagen-related peptide (CRP) and receptor-activating peptide-6 (TRAP).
ISSN:1073-449X
1535-4970