C28 FROM TARGETS TO THERAPIES IN FIBROSIS: S100a4 Is Necessary For Lung Mesenchymal Progenitor Cell Fibrogenicity In Ipf

Immunohistochemical analysis of IPF patient lung tissue was performed to assess the location of IPF MPCs expressing S100A4 in relation to developing fibroblastic foci lesions. In IPF lung tissue specimens, fibroblastic foci contained cells expressing SSEA4, S100A4 and Ki67 that co-localized to the p...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Henke, C A, Xia, H, Gilbertsen, A, Herrera, J, Racila, E, Smith, K, Griffin, T, Benyumov, A, Yang, L, Bitterman, P
Format: Article
Language:English
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Rodents
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Summary:Immunohistochemical analysis of IPF patient lung tissue was performed to assess the location of IPF MPCs expressing S100A4 in relation to developing fibroblastic foci lesions. In IPF lung tissue specimens, fibroblastic foci contained cells expressing SSEA4, S100A4 and Ki67 that co-localized to the periphery of the focus in an interface region between myofibroblasts in the focus core and normal alveolar structures; defining this region as an active fibrotic front.
ISSN:1073-449X
1535-4970