D25 UNUSUAL INFECTIONS: CASE REPORTS: Flow Cytometric Immune Profiling In A Patient With Culture-Negative Tuberculosis

Recent data suggest that detection of co-expression of surface markers CD25 (a subunit of IL-2 receptor) and OX40 (CD134, a TNFa receptor) by flow cytometry (FC) can accurately identify antigen-specific effector CD4+ and CD8+ T-cell activation in LTBI and also in immunosuppressed TB patients. Specif...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: McCambridge, A, Peikert, T, Van Keulen, V, Erskine, C, Escalante, P
Format: Article
Language:English
Subjects:
Antigens
T cell receptors
Tuberculosis
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Summary:Recent data suggest that detection of co-expression of surface markers CD25 (a subunit of IL-2 receptor) and OX40 (CD134, a TNFa receptor) by flow cytometry (FC) can accurately identify antigen-specific effector CD4+ and CD8+ T-cell activation in LTBI and also in immunosuppressed TB patients. Specifically, peripheral blood mononuclear cells were separated with a FICOLL™ method and stimulated with specific (RDl-peptides) and purified protein derivate (PPD) antigens and controls.
ISSN:1073-449X
1535-4970