C34 MECHANISMS OF HOST DEFENSE IN BACTERIAL AND FUNGAL INFECTIONS: Hypercapnia Decreases Antiviral Proteins And Increases Viral Replication In Macrophages Infected With Influenza A Virus Through An Akt Dependent Mechanism

In the current study, we explore the effects of hypercapnia-induced Akt on the expression of antiviral proteins including MX dynamin like GTPase 1 (MX1), 2'-5'-oligoadenylate synthetase 1 (OAS1) and viperin; viral nonstructural 1 protein 1 (NS1) and NP; and viral replication in human and m...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Casalino-Matsuda, M, Gonzalez, F, Chi, M, Nair, A, Gates, K L, Budinger, G S, Sporn, P H
Format: Article
Language:English
Subjects:
Antiviral drugs
Infections
Influenza
Proteins
Rodents
Viral infections
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Summary:In the current study, we explore the effects of hypercapnia-induced Akt on the expression of antiviral proteins including MX dynamin like GTPase 1 (MX1), 2'-5'-oligoadenylate synthetase 1 (OAS1) and viperin; viral nonstructural 1 protein 1 (NS1) and NP; and viral replication in human and murine macrophages. The effect of hypercapnia on the macrophage antiviral response and virus production can be blocked by a small molecule inhibitor of Akt, suggesting a pharmacologic strategy to ameliorate hypercapnia-induced suppression of antiviral host defense in patients with advanced lung disease and hypercapnia.
ISSN:1073-449X
1535-4970