C76 HEAT SHOCK PROTEIN: The Role Of Intracellular Heat Shock Protein 70 Deficiency In Idiopathic Pulmonary Fibrosis

Treatment of primary human lung fibroblasts in vitro with IGFBP-5 or TGF-ß1 decreased Hsp70 in parallel with increased extracellular matrix proteins, collagen and fibronectin. The project described was supported in part by the National Institutes of Health through Grant Numbers R01 AR050840 (CFB), K...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Sellares, J, Thiel, K J, Cardenes, N, Schneider, F, Pilewski, J M, Rojas, M, Feghali-Bostwick, C A, Veraldi, K L
Format: Article
Language:English
Subjects:
Aging
Fibroblasts
Heat shock proteins
Lungs
Pulmonary fibrosis
Rodents
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Summary:Treatment of primary human lung fibroblasts in vitro with IGFBP-5 or TGF-ß1 decreased Hsp70 in parallel with increased extracellular matrix proteins, collagen and fibronectin. The project described was supported in part by the National Institutes of Health through Grant Numbers R01 AR050840 (CFB), K08 HL094764 (KLV), P30 DK 072506 (Human Airway Cell and Tissue Core, JMP), Pilot Project Program through UL1 RR024153 and UL1 TR000005 (University of Pittsburgh CTSI award to KLV), Cystic Fibrosis Foundation Research Development Program Grant (Human Airway Cell and Tissue Core, JMP) and by the Samuel and Emma Winters Foundation for Biomedical Research (KLV) Am J Respir Crit Care Med 2017;195:
ISSN:1073-449X
1535-4970