C76 HEAT SHOCK PROTEIN: The Role Of Intracellular Heat Shock Protein 70 Deficiency In Idiopathic Pulmonary Fibrosis

Treatment of primary human lung fibroblasts in vitro with IGFBP-5 or TGF-ß1 decreased Hsp70 in parallel with increased extracellular matrix proteins, collagen and fibronectin. The project described was supported in part by the National Institutes of Health through Grant Numbers R01 AR050840 (CFB), K...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Sellares, J, Thiel, K J, Cardenes, N, Schneider, F, Pilewski, J M, Rojas, M, Feghali-Bostwick, C A, Veraldi, K L
Format: Article
Language:English
Subjects:
Aging
Fibroblasts
Heat shock proteins
Lungs
Pulmonary fibrosis
Rodents
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue
container_start_page
container_title American journal of respiratory and critical care medicine
container_volume 195
creator Sellares, J
Thiel, K J
Cardenes, N
Schneider, F
Pilewski, J M
Rojas, M
Feghali-Bostwick, C A
Veraldi, K L
description Treatment of primary human lung fibroblasts in vitro with IGFBP-5 or TGF-ß1 decreased Hsp70 in parallel with increased extracellular matrix proteins, collagen and fibronectin. The project described was supported in part by the National Institutes of Health through Grant Numbers R01 AR050840 (CFB), K08 HL094764 (KLV), P30 DK 072506 (Human Airway Cell and Tissue Core, JMP), Pilot Project Program through UL1 RR024153 and UL1 TR000005 (University of Pittsburgh CTSI award to KLV), Cystic Fibrosis Foundation Research Development Program Grant (Human Airway Cell and Tissue Core, JMP) and by the Samuel and Emma Winters Foundation for Biomedical Research (KLV) Am J Respir Crit Care Med 2017;195:
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1926719250</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1926719250</sourcerecordid><originalsourceid>FETCH-proquest_journals_19267192503</originalsourceid><addsrcrecordid>eNqNir1qwzAURkVoIWnad7jQ2SD_RXG24jrYFGpje8hmVOUaK1GlVJKHvH099AG6nO_Ad1ZkE6ZxGiQZow-LUxYHSZKd1uTJuQulYbQP6Ya4nO2gLN566Mo6_4Cmrfui-jxAPyG0RiHUI1TaWy5QqVlxCyVyD91kxBUaazxKDYzCO45SSNTivuRQnaW5cT9JAc2svo3m9g5H-WWNk-6ZPI5cOXz52y15PRZ9XgY3a35mdH64mNnq5RrCLNqxBSmN_1f9Ak7tSX8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1926719250</pqid></control><display><type>article</type><title>C76 HEAT SHOCK PROTEIN: The Role Of Intracellular Heat Shock Protein 70 Deficiency In Idiopathic Pulmonary Fibrosis</title><source>Freely Accessible Science Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Sellares, J ; Thiel, K J ; Cardenes, N ; Schneider, F ; Pilewski, J M ; Rojas, M ; Feghali-Bostwick, C A ; Veraldi, K L</creator><creatorcontrib>Sellares, J ; Thiel, K J ; Cardenes, N ; Schneider, F ; Pilewski, J M ; Rojas, M ; Feghali-Bostwick, C A ; Veraldi, K L</creatorcontrib><description>Treatment of primary human lung fibroblasts in vitro with IGFBP-5 or TGF-ß1 decreased Hsp70 in parallel with increased extracellular matrix proteins, collagen and fibronectin. The project described was supported in part by the National Institutes of Health through Grant Numbers R01 AR050840 (CFB), K08 HL094764 (KLV), P30 DK 072506 (Human Airway Cell and Tissue Core, JMP), Pilot Project Program through UL1 RR024153 and UL1 TR000005 (University of Pittsburgh CTSI award to KLV), Cystic Fibrosis Foundation Research Development Program Grant (Human Airway Cell and Tissue Core, JMP) and by the Samuel and Emma Winters Foundation for Biomedical Research (KLV) Am J Respir Crit Care Med 2017;195:</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><language>eng</language><publisher>New York: American Thoracic Society</publisher><subject>Aging ; Fibroblasts ; Heat shock proteins ; Lungs ; Pulmonary fibrosis ; Rodents</subject><ispartof>American journal of respiratory and critical care medicine, 2017-01, Vol.195</ispartof><rights>Copyright American Thoracic Society 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Sellares, J</creatorcontrib><creatorcontrib>Thiel, K J</creatorcontrib><creatorcontrib>Cardenes, N</creatorcontrib><creatorcontrib>Schneider, F</creatorcontrib><creatorcontrib>Pilewski, J M</creatorcontrib><creatorcontrib>Rojas, M</creatorcontrib><creatorcontrib>Feghali-Bostwick, C A</creatorcontrib><creatorcontrib>Veraldi, K L</creatorcontrib><title>C76 HEAT SHOCK PROTEIN: The Role Of Intracellular Heat Shock Protein 70 Deficiency In Idiopathic Pulmonary Fibrosis</title><title>American journal of respiratory and critical care medicine</title><description>Treatment of primary human lung fibroblasts in vitro with IGFBP-5 or TGF-ß1 decreased Hsp70 in parallel with increased extracellular matrix proteins, collagen and fibronectin. The project described was supported in part by the National Institutes of Health through Grant Numbers R01 AR050840 (CFB), K08 HL094764 (KLV), P30 DK 072506 (Human Airway Cell and Tissue Core, JMP), Pilot Project Program through UL1 RR024153 and UL1 TR000005 (University of Pittsburgh CTSI award to KLV), Cystic Fibrosis Foundation Research Development Program Grant (Human Airway Cell and Tissue Core, JMP) and by the Samuel and Emma Winters Foundation for Biomedical Research (KLV) Am J Respir Crit Care Med 2017;195:</description><subject>Aging</subject><subject>Fibroblasts</subject><subject>Heat shock proteins</subject><subject>Lungs</subject><subject>Pulmonary fibrosis</subject><subject>Rodents</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNir1qwzAURkVoIWnad7jQ2SD_RXG24jrYFGpje8hmVOUaK1GlVJKHvH099AG6nO_Ad1ZkE6ZxGiQZow-LUxYHSZKd1uTJuQulYbQP6Ya4nO2gLN566Mo6_4Cmrfui-jxAPyG0RiHUI1TaWy5QqVlxCyVyD91kxBUaazxKDYzCO45SSNTivuRQnaW5cT9JAc2svo3m9g5H-WWNk-6ZPI5cOXz52y15PRZ9XgY3a35mdH64mNnq5RrCLNqxBSmN_1f9Ak7tSX8</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Sellares, J</creator><creator>Thiel, K J</creator><creator>Cardenes, N</creator><creator>Schneider, F</creator><creator>Pilewski, J M</creator><creator>Rojas, M</creator><creator>Feghali-Bostwick, C A</creator><creator>Veraldi, K L</creator><general>American Thoracic Society</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170101</creationdate><title>C76 HEAT SHOCK PROTEIN: The Role Of Intracellular Heat Shock Protein 70 Deficiency In Idiopathic Pulmonary Fibrosis</title><author>Sellares, J ; Thiel, K J ; Cardenes, N ; Schneider, F ; Pilewski, J M ; Rojas, M ; Feghali-Bostwick, C A ; Veraldi, K L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_19267192503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aging</topic><topic>Fibroblasts</topic><topic>Heat shock proteins</topic><topic>Lungs</topic><topic>Pulmonary fibrosis</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sellares, J</creatorcontrib><creatorcontrib>Thiel, K J</creatorcontrib><creatorcontrib>Cardenes, N</creatorcontrib><creatorcontrib>Schneider, F</creatorcontrib><creatorcontrib>Pilewski, J M</creatorcontrib><creatorcontrib>Rojas, M</creatorcontrib><creatorcontrib>Feghali-Bostwick, C A</creatorcontrib><creatorcontrib>Veraldi, K L</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing &amp; Allied Health Source</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sellares, J</au><au>Thiel, K J</au><au>Cardenes, N</au><au>Schneider, F</au><au>Pilewski, J M</au><au>Rojas, M</au><au>Feghali-Bostwick, C A</au><au>Veraldi, K L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C76 HEAT SHOCK PROTEIN: The Role Of Intracellular Heat Shock Protein 70 Deficiency In Idiopathic Pulmonary Fibrosis</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><date>2017-01-01</date><risdate>2017</risdate><volume>195</volume><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Treatment of primary human lung fibroblasts in vitro with IGFBP-5 or TGF-ß1 decreased Hsp70 in parallel with increased extracellular matrix proteins, collagen and fibronectin. The project described was supported in part by the National Institutes of Health through Grant Numbers R01 AR050840 (CFB), K08 HL094764 (KLV), P30 DK 072506 (Human Airway Cell and Tissue Core, JMP), Pilot Project Program through UL1 RR024153 and UL1 TR000005 (University of Pittsburgh CTSI award to KLV), Cystic Fibrosis Foundation Research Development Program Grant (Human Airway Cell and Tissue Core, JMP) and by the Samuel and Emma Winters Foundation for Biomedical Research (KLV) Am J Respir Crit Care Med 2017;195:</abstract><cop>New York</cop><pub>American Thoracic Society</pub></addata></record>
fulltext fulltext
identifier ISSN: 1073-449X
ispartof American journal of respiratory and critical care medicine, 2017-01, Vol.195
issn 1073-449X
1535-4970
language eng
recordid cdi_proquest_journals_1926719250
source Freely Accessible Science Journals; EZB-FREE-00999 freely available EZB journals
subjects Aging
Fibroblasts
Heat shock proteins
Lungs
Pulmonary fibrosis
Rodents
title C76 HEAT SHOCK PROTEIN: The Role Of Intracellular Heat Shock Protein 70 Deficiency In Idiopathic Pulmonary Fibrosis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T10%3A34%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=C76%20HEAT%20SHOCK%20PROTEIN:%20The%20Role%20Of%20Intracellular%20Heat%20Shock%20Protein%2070%20Deficiency%20In%20Idiopathic%20Pulmonary%20Fibrosis&rft.jtitle=American%20journal%20of%20respiratory%20and%20critical%20care%20medicine&rft.au=Sellares,%20J&rft.date=2017-01-01&rft.volume=195&rft.issn=1073-449X&rft.eissn=1535-4970&rft_id=info:doi/&rft_dat=%3Cproquest%3E1926719250%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_19267192503%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1926719250&rft_id=info:pmid/&rfr_iscdi=true