A72 MECHANISMS DRIVING FIBROSIS: Expression Of Tgfβ Activators By Bronchial Epithelial Cells (becs) From Asthmatic And Healthy Children

TGFß2 is the predominant isoform produced by BECs, whereas the predominant isoform secreted by human lung fibroblasts (HLF) is TGFßl. Aims: (1) Determine if expression of the potential TGFß activators avß6 integrin, thrombospondin-1 (TSP-1), and/or matrix metalloproteinases (MMPs) 2, 9, 14 is greate...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Barrow, K, Reeves, S R, Kolstad, T, White, M, Naushab, M, Debley, J S
Format: Article
Language:English
Subjects:
Airway management
Asthma
Fibroblasts
Proteins
Online Access:Get full text
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Summary:TGFß2 is the predominant isoform produced by BECs, whereas the predominant isoform secreted by human lung fibroblasts (HLF) is TGFßl. Aims: (1) Determine if expression of the potential TGFß activators avß6 integrin, thrombospondin-1 (TSP-1), and/or matrix metalloproteinases (MMPs) 2, 9, 14 is greater by BECs grown ex vivo from asthmatic children with baseline airway obstruction than by BECs from healthy children, and (2) compare the concentration of active TGFß1 in shared media from asthmatic and healthy BEC-HLF co-cultures.
ISSN:1073-449X
1535-4970