D29 UNRAVELING THE EXTRACELLULAR MATRIX: The Role Of Interleukin-1 In Driving Inflammation And Remodeling In The Asthmatic Emtu

Rational: Asthma is a chronic inflammatory disease associated with airway remodeling that involves all tissues of the airway wall, including the epithelium, mesenchymal cells and extracellular matrix (ECM), which together form the epithelial-mesenchymal trophic unit (EMTU). SHG-NLOM analysis reveale...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Osei, E T, Mostaco-Guidolin, L, Warner, S, Hallstrand, T S, Timens, W, Postma, D S, Brandsma, C A, Heijink, I H, Hackett, T-L
Format: Article
Language:English
Subjects:
Asthma
Collagen
Extracellular matrix
Fibroblasts
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rational: Asthma is a chronic inflammatory disease associated with airway remodeling that involves all tissues of the airway wall, including the epithelium, mesenchymal cells and extracellular matrix (ECM), which together form the epithelial-mesenchymal trophic unit (EMTU). SHG-NLOM analysis revealed that IL-1a and IL-1ß but not IL-33 inhibited the ability of PAFs to remodel gelatin into fibrillar collagen I. mRNA expression of GLI1, a known regulator of collagen synthesis, and of lysyl oxidase, a collagen cross-linking enzyme, were found to be down-regulated with IL-1 treatment in fibroblasts.
ISSN:1073-449X
1535-4970