A34 CLINICAL AND CELLULAR STUDIES IN ALLERGIC DISEASE: Origin, Phenotype And Function Of Human Ige Cells

Rationale Immunoglobulin E (IgE) plays a central role in allergic diseases due to its ability to bind to high-affinity receptors on mast cells and induce degranulation upon allergen crosslinking. GO analysis of IgE DEG demonstrated that IgE cells expressed genes associated with N-glycosylation, the...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: De Lafaille, M A Curotto, Narayanan, S, Narang, V, Wong, G, Aw, D C W, Chandran, N, Saunders, S, Navin, I, Reibman, J, Poidinger, M, Zolezzi, F
Format: Article
Language:English
Subjects:
Flow cytometry
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Summary:Rationale Immunoglobulin E (IgE) plays a central role in allergic diseases due to its ability to bind to high-affinity receptors on mast cells and induce degranulation upon allergen crosslinking. GO analysis of IgE DEG demonstrated that IgE cells expressed genes associated with N-glycosylation, the IRE1-XBP1 endoplasmic reticulum unfolded protein response, and mitochondrial oxidative phosphorylation, all indicative of a plasma cell program.
ISSN:1073-449X
1535-4970