C35 ASTHMA AND ALLERGY CELLULAR INVESTIGATIONS: Interaction Of Type 2 Cytotoxic T Lymphocytes And Mast Cell Lipid Mediators Contributes To Pathogenesis Of Eosinophilic Asthma

The effects of PGD2, LTE4 alone or their combination on the cell migration were measured with a chemotaxis assay; and on cytokine production and gene regulation were examined by using microarray, qPCR, ELISA and luminex. The activation of Tc2 cells could be an important contributor to eosinophilia....

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Xue, L, Stoeger, L, Marchi, E, Liu, W, Go, S, Kurioka, A, Leng, T, Salimi, M, Shrimanker, R, Powell, T, Ramasamy, A, Ogg, G, Pavord, I, Klenerman, P
Format: Article
Language:English
Subjects:
Asthma
Cytokines
Cytotoxicity
Lipids
Pathogenesis
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Summary:The effects of PGD2, LTE4 alone or their combination on the cell migration were measured with a chemotaxis assay; and on cytokine production and gene regulation were examined by using microarray, qPCR, ELISA and luminex. The activation of Tc2 cells could be an important contributor to eosinophilia. [...]Tc2 cells and mast cell lipid mediator are important targets for therapeutic intervention to control eosinophilic asthma.
ISSN:1073-449X
1535-4970