C35 ASTHMA AND ALLERGY CELLULAR INVESTIGATIONS: Interaction Of Type 2 Cytotoxic T Lymphocytes And Mast Cell Lipid Mediators Contributes To Pathogenesis Of Eosinophilic Asthma

The effects of PGD2, LTE4 alone or their combination on the cell migration were measured with a chemotaxis assay; and on cytokine production and gene regulation were examined by using microarray, qPCR, ELISA and luminex. The activation of Tc2 cells could be an important contributor to eosinophilia....

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Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Xue, L, Stoeger, L, Marchi, E, Liu, W, Go, S, Kurioka, A, Leng, T, Salimi, M, Shrimanker, R, Powell, T, Ramasamy, A, Ogg, G, Pavord, I, Klenerman, P
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Language:English
Subjects:
Asthma
Cytokines
Cytotoxicity
Lipids
Pathogenesis
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container_title American journal of respiratory and critical care medicine
container_volume 195
creator Xue, L
Stoeger, L
Marchi, E
Liu, W
Go, S
Kurioka, A
Leng, T
Salimi, M
Shrimanker, R
Powell, T
Ramasamy, A
Ogg, G
Pavord, I
Klenerman, P
description The effects of PGD2, LTE4 alone or their combination on the cell migration were measured with a chemotaxis assay; and on cytokine production and gene regulation were examined by using microarray, qPCR, ELISA and luminex. The activation of Tc2 cells could be an important contributor to eosinophilia. [...]Tc2 cells and mast cell lipid mediator are important targets for therapeutic intervention to control eosinophilic asthma.
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source Freely Accessible Science Journals - check A-Z of ejournals; EZB Electronic Journals Library
subjects Asthma
Cytokines
Cytotoxicity
Lipids
Pathogenesis
title C35 ASTHMA AND ALLERGY CELLULAR INVESTIGATIONS: Interaction Of Type 2 Cytotoxic T Lymphocytes And Mast Cell Lipid Mediators Contributes To Pathogenesis Of Eosinophilic Asthma
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