D92 BASIC MECHANISMS OF LUNG ALLOGRAFT REJECTION: Airway Microbiota Signals Anabolic And Catabolic Remodeling In The Transplanted Lung

Direct microbial impact on remodeling gene expression and matrix deposition was measured by RT-qPCR and immunofluorescence, respectively, by using an in vitro co-culture system of macrophages-fibroblasts exposed to either separate species or mixed combinations of four bacteria representing dominant...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Mouraux, S, Bernasconi, E, Pattaroni, C, Koutsokera, A, Pison, C, Kessler, R, Benden, C, Gasche-Soccal, P, Magnan, A, Aubert, J-D, Marsland, B J, Nicod, L P
Format: Article
Language:English
Subjects:
Bacteria
Gene expression
Transplants & implants
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Summary:Direct microbial impact on remodeling gene expression and matrix deposition was measured by RT-qPCR and immunofluorescence, respectively, by using an in vitro co-culture system of macrophages-fibroblasts exposed to either separate species or mixed combinations of four bacteria representing dominant genera of the respiratory microbiota in non-infected or infected lung transplant recipients. [...]monitoring host-microbiota interactions may enable us to increase our understanding of CLAD onset and, by extension, the pathophysiology of fibroproliferative respiratory conditions.
ISSN:1073-449X
1535-4970