A67 BREAKDOWN: THE CELLULAR CONTRIBUTION TO PULMONARY HYPERTENSION: The Role Of Hifs In Maintaining Pulmonary Artery Fibroblast Phenotypes In Pulmonary Hypertension

Rationale: In the lung, prolonged exposure to hypoxia results in sustained vasoconstriction, pulmonary vascular remodeling, and the development of pulmonary hypertension (PH). [...]different from previous studies, the aim of this study was to analyze the role of HIFs in maintaining vascular cell phe...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Zhang, H, Hu, C-J, Li, M, Flockton, A, Stenmark, K R
Format: Article
Language:English
Subjects:
Fibroblasts
Gene expression
Hypoxia
Metabolism
Proteins
Pulmonary arteries
Pulmonary hypertension
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Summary:Rationale: In the lung, prolonged exposure to hypoxia results in sustained vasoconstriction, pulmonary vascular remodeling, and the development of pulmonary hypertension (PH). [...]different from previous studies, the aim of this study was to analyze the role of HIFs in maintaining vascular cell phenotypes at the later stage of PH.
ISSN:1073-449X
1535-4970