C74 ADVANCES IN TRANSLATIONAL COPD: Inhaled Alpha-1-Antitrypsin Restores Lower Respiratory Tract Protease- Anti-Protease Homeostasis And Reduces Inflammation In Alpha-1 Antitrypsin Deficient Individuals: A Phase 2 Clinical Study Using Inhaled Kamada-Api

Corresponding author's email: brantml@medicine.ufl.edu Introduction: Alpha-1-Antitrypsin (AAT) deficient individuals are at substantially greater risk of developing COPD following exposure to cigarette or passive smoking compared to individuals with normal amounts of AAT. Anti-neutrophil elasta...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Brantly, M, Stocks, J, Rouhani, F, Lascano, J, Jeffers, A, Nolte, J, Owens, S, Tucker, T A, Tov, N
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Cytokines
Homeostasis
Neutrophils
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Corresponding author's email: brantml@medicine.ufl.edu Introduction: Alpha-1-Antitrypsin (AAT) deficient individuals are at substantially greater risk of developing COPD following exposure to cigarette or passive smoking compared to individuals with normal amounts of AAT. Anti-neutrophil elastase capacity (ANEC), %PMNs, NE, AAT, NE-AAT complex and a panel of inflammatory cytokines were measured and adjusted for the epithelial lining fluid (ELF) volume using the urea method.
ISSN:1073-449X
1535-4970