C74 ADVANCES IN TRANSLATIONAL COPD: A Novel Proteogenomics Approach Identifying Key Proteins In Severe COPD

[...]we performed a combined proteome and RNA sequencing analysis comparing severe COPD and non-COPD control lung tissue. MFAP4, a protein present in elastic fibres, is of particular interest since we previously found increased MFAP4 gene expression levels in lung tissue samples from a more heteroge...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Brandsma, C A, Guryev, V, Timens, W, Postma, D S, Bischoff, R, Yakovleva, M, Marko-Varga, G, Fehniger, T, van den Berge, M, Horvatovich, P
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Cytokines
Gene expression
Kinases
Protein expression
Proteins
Online Access:Get full text
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Summary:[...]we performed a combined proteome and RNA sequencing analysis comparing severe COPD and non-COPD control lung tissue. MFAP4, a protein present in elastic fibres, is of particular interest since we previously found increased MFAP4 gene expression levels in lung tissue samples from a more heterogeneous group of COPD patients using mRNA arrays.
ISSN:1073-449X
1535-4970