A28 EXOSOMES AND MICRORNA: Microrna 24, 145, 191 And 221 Found In Human Bronchoalveolar Lavage Suppresses Endotoxin-Induced Nf-Kappa B Activation And Tnf-Alpha Production

[...]the functional role of these miRNAs under these conditions has not been defined. [...]we sought to extend these observations to assess their effects on activation of the NFkB pathway. Conclusions: miRNAs 24, 145, 191 and 221 found in human bronchoalveolar lavage after endotoxin-challenge have t...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Gairhe, S, Narute, P, Sun, J, Suffredini, A F
Format: Article
Language:English
Subjects:
Gene expression
MicroRNAs
Transcription factors
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Summary:[...]the functional role of these miRNAs under these conditions has not been defined. [...]we sought to extend these observations to assess their effects on activation of the NFkB pathway. Conclusions: miRNAs 24, 145, 191 and 221 found in human bronchoalveolar lavage after endotoxin-challenge have the potential to regulate inflammation by suppressing NF kB pathway activation and TNF-a production.
ISSN:1073-449X
1535-4970