C21 OMICS IN LUNG DISEASE: Whole Genome Sequencing Study On Bronchodilator Drug Response In Ethnically Diverse Children With Asthma

Despite significant racial/ethnic variation in bronchodilator drug response (BDR), albuterol is often the only medication prescribed for asthma, regardless of disease severity. Methods We performed whole genome sequencing on 1,500 ethnically diversed children with asthma from the extremes of broncho...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Mak, A, White, M J, Szpiech, Z A, Eckalbar, W, Pino-Yanes, M, Oh, S, Hu, D, Huntsman, S, Eng, C, Davis, A, Serebrisky, D, Brigino-Buenaventura, E, Lurmann, F, Farber, H J, Rodriguez-Santana, J R, Meade, K, Borrell, L N, LeNoir, M A, Avila, P C, Kumar, R, Sen, S, Thyne, S, Rodriguez-Cintron, W, Kwok, P-Y, Torgerson, D G, Galanter, J, Ahituv, N, Ziv, E, Seibold, M A, Zaitlen, N, Hernandez, R D, Burchard, E G
Format: Article
Language:English
Subjects:
Asthma
Genomes
Population
Online Access:Get full text
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Summary:Despite significant racial/ethnic variation in bronchodilator drug response (BDR), albuterol is often the only medication prescribed for asthma, regardless of disease severity. Methods We performed whole genome sequencing on 1,500 ethnically diversed children with asthma from the extremes of bronchodilator drug response to albuterol.
ISSN:1073-449X
1535-4970