A67 BREAKDOWN: THE CELLULAR CONTRIBUTION TO PULMONARY HYPERTENSION: Leukotriene B4 Potentiates Bmpr2 Deficiency And Causes Paec Endmt In Pah

LTB4 directly inhibited BMPR2 signaling in vitro through up-regulation of TGF beta pathway. [...]over-expression of LTB4 in the lung of BMPR2+/- rat carrying a 527 bp frame-shift mutation on exon 5 caused severe PH. [...]we have demonstrated that LTB4 worked in concert with BMPR2 dysfunction that su...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Tian, A, Jiang, X, Shuffle, E, Tu, A, Jin, Q, Zamanian, R T, Voelkel, N, Peters-Golden, M, Tuder, R, Rabinovitch, M, Nicolls, M
Format: Article
Language:English
Subjects:
Apoptosis
Hypertension
Inflammation
Pulmonary arteries
Online Access:Get full text
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Summary:LTB4 directly inhibited BMPR2 signaling in vitro through up-regulation of TGF beta pathway. [...]over-expression of LTB4 in the lung of BMPR2+/- rat carrying a 527 bp frame-shift mutation on exon 5 caused severe PH. [...]we have demonstrated that LTB4 worked in concert with BMPR2 dysfunction that sustained inflammation and promoted severe PAH by causing PAECs injury and EndMT.
ISSN:1073-449X
1535-4970