C78 FIBROSIS: MEDIATORS AND MODULATORS: Resokine Modulates Immune Cell Infiltration Into The Lung And Provides Therapeutic Activity In A Bleomycin-Induced Lung Fibrosis Model

Rationale: Patients with auto-antibodies specific for Resokine have notable T-cell infiltration particularly into muscle and lung tissues which may manifest as susceptibility to myositis and interstitial lung disease (ILD). [...]blocking of potential immunomodulatory functions of Resokine may be par...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Ogilvie, K M, Do, M T, Chiang, K P, Adams, R A, Crampton, S P, Nangle, L A, Cubitt, A B, McKew, J C, Ashlock, M A, Mendlein, J D
Format: Article
Language:English
Subjects:
Inflammatory diseases
Interferon
Lung diseases
Musculoskeletal diseases
Proteins
Rodents
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Summary:Rationale: Patients with auto-antibodies specific for Resokine have notable T-cell infiltration particularly into muscle and lung tissues which may manifest as susceptibility to myositis and interstitial lung disease (ILD). [...]blocking of potential immunomodulatory functions of Resokine may be particularly important in these diseases. Methods: We tested effects of mouse or human Resolaris, and iMod-Fc, a Resokine n-terminal splice variant (SV9) fused to human Fc, for their ability to ameliorate lung pathology in bleomycin-induced lung fibrosis.
ISSN:1073-449X
1535-4970