C74 ADVANCES IN TRANSLATIONAL COPD: Effects Of A Pparã And Lxr Agonists Combination Therapy On The Pulmonary Response To Cigarette Smoke

Hypothesis: Concomitant pharmacological activation of PPARy and LXR receptors will promote pulmonary lipid export in response to cigarette smoke, reducing the magnitude of the inflammatory response. Lung tissue and bronchoalveolar lavage (BAL) were collected to analyse lung inflammation (total cells...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Jubinville, E, Maranda-Robitaille, M, Talbot, M, Thibault, C, Page, M, Beaulieu, M-J, Pilote, S, Aubin, S, Pare, M-E, Drolet, B, Simard, C, Morissette, M C
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Cigarettes
Combination therapy
Lipids
Tobacco smoke
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypothesis: Concomitant pharmacological activation of PPARy and LXR receptors will promote pulmonary lipid export in response to cigarette smoke, reducing the magnitude of the inflammatory response. Lung tissue and bronchoalveolar lavage (BAL) were collected to analyse lung inflammation (total cells counts, differentials, ELISA) and expression of key genes involved in lipid transport (abca1, abcg1 and apoe) were assessed.
ISSN:1073-449X
1535-4970