A93 ROLE OF ADAPTIVE IMMUNITY IN LUNG DISEASE: Type 2 Cytotoxic T Lymphocytes In Patients With Severe Eosinophilic Asthma

Using CD3+CD4+IL-13 and CD3+CD8+IL-13 as biomarkers for Th2 and Tc2 respectively, we FACS compared the profiles of these cells in blood, bronchial biopsies, BAL and sputa from healthy controls (22) and patients with non-eosinophilic (42) and eosinophilic (10) asthma in Southampton cohort. Tc2 cells...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Xue, L, Hilvering, B, Hinks, T, Stoeger, L, Shrimanker, R, Go, S, Borg, C, Connolly, C, Thulborn, S J, Pavord, I
Format: Article
Language:English
Subjects:
Asthma
Biomarkers
Cytokines
Cytotoxicity
Lymphocytes
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Summary:Using CD3+CD4+IL-13 and CD3+CD8+IL-13 as biomarkers for Th2 and Tc2 respectively, we FACS compared the profiles of these cells in blood, bronchial biopsies, BAL and sputa from healthy controls (22) and patients with non-eosinophilic (42) and eosinophilic (10) asthma in Southampton cohort. Tc2 cells were enriched in both peripheral blood and lung tissues (Table).
ISSN:1073-449X
1535-4970