C15 WHEN MICROBES ATTACK: HOST-PATHOGEN INTERACTIONS: Protection Against Viral Pneumonia Following Inhalation Of Synergistic Tlr Agonists Is Not Mediated By Induction Of Type I Interferons

Toll-like receptors (TLRs) play crucial roles in innate immune responses to viral pathogens, and TLR-mediated virus detection is well established to often induce type I IFN production from lung epithelial cells, the principal target cell of many respiratory viruses. Methods: Primary mouse tracheal e...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Wali, S, Wang, Y, Leiva-Juarez, M M, Kulkarni, V V, Sunkesula, S Bhupanapadu, Batres, S, Goldblatt, D L, Flores, J, Tuvim, M J, Evans, S E
Format: Article
Language:English
Subjects:
Hypotheses
Interferon
Pneumonia
Viral infections
Viruses
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Toll-like receptors (TLRs) play crucial roles in innate immune responses to viral pathogens, and TLR-mediated virus detection is well established to often induce type I IFN production from lung epithelial cells, the principal target cell of many respiratory viruses. Methods: Primary mouse tracheal epithelial cells (mTECs) were treated with Pam2-ODN (or sham) prior to infection with influenza A or Sendai virus, then protein levels of type I IFN were assessed by ELISA.
ISSN:1073-449X
1535-4970