A74 REGULATORY MECHANISMS OF THE MOLECULAR PATHWAYS IN FIBROSIS: Tlr5 Protects From The Development Of Pulmonary Fibrosis

In bone marrow chimeras, epithelial TLR5 mediates the protection from fibrosis, while myeloid TLR5 has little effect. Excitingly, the TLR5 agonist entolimod, which is currently used in clinical trials, protects from experimental lung fibrosis.

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Garantziotis, S, Johnson, C G, Hussain, S, Zhang, Y, Tighe, R M, Gudkov, A
Format: Article
Language:English
Subjects:
Pulmonary fibrosis
Rodents
Online Access:Get full text
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Description
Summary:In bone marrow chimeras, epithelial TLR5 mediates the protection from fibrosis, while myeloid TLR5 has little effect. Excitingly, the TLR5 agonist entolimod, which is currently used in clinical trials, protects from experimental lung fibrosis.
ISSN:1073-449X
1535-4970