C39 BIOMARKERS AND PROGNOSTIC FACTORS IN ILD: Expression Of B-Cell Activating Factor Belonging To The Tnf Family (baff) In Patients With Sarcoidosis

(Discussion) Plasmatic hypergammaglobulinemia has been found in patients with active sarcoidosis, and a beneficial effect of anti-CD20 monoclonal antibody B cell-depleting therapy has been reported in some refractory cases, suggesting that B cells may play an important role in the pathogenesis. A re...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Ando, M, Goto, A, Uchida, S, Matsumoto, H, Ono, T, Usagawa, Y, Jo, K, Takeno, Y, Yasuda, C, Mizukami, E, Yamasue, M, Hashinaga, K, Yoshikawa, H, Toba, S, Umeki, K, Nureki, S-I, Takenaka, R-I, Ishii, T, Hiramatsu, K, Miyazaki, E, Kadota, J-I
Format: Article
Language:English
Subjects:
Medical prognosis
Pathogenesis
Sarcoidosis
Online Access:Get full text
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Summary:(Discussion) Plasmatic hypergammaglobulinemia has been found in patients with active sarcoidosis, and a beneficial effect of anti-CD20 monoclonal antibody B cell-depleting therapy has been reported in some refractory cases, suggesting that B cells may play an important role in the pathogenesis. A recent study demonstrated that BAFF can promote T cell activation, proliferation and differentiation. [...]BAFF may contribute to disease progression via not only B cells but also T cells in the pathogenesis of sarcoidosis.
ISSN:1073-449X
1535-4970