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A106 HOST-PATHOGEN INTERACTIONS: Angiopoietin-2 In Pneumococcal Pneumonia: Insights From A Novel Inducible Ang-2 Knockout Mouse

[...]the role of Ang-2 in pneumonia-induced hyperinflammation needs to be elucidated. [...]we newly established an inducible Ang-2-knockout (KO) mouse model (because constitutive Ang-2 deletion can result in early postnatal vascular and lymphatic damage) and investigated the impact of Ang-2 on pulmo...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Gutbier, B, Ehrler, C, Dietert, K, Nouailles-Kursar, G, Kershaw, O, Mitchell, T J, Gruber, A D, Weissmann, N, Suttorp, N, Witzenrath, M
Format: Article
Language:English
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Summary:[...]the role of Ang-2 in pneumonia-induced hyperinflammation needs to be elucidated. [...]we newly established an inducible Ang-2-knockout (KO) mouse model (because constitutive Ang-2 deletion can result in early postnatal vascular and lymphatic damage) and investigated the impact of Ang-2 on pulmonary endothelial barrier function. Compared to WT mice, Ang-2-KO mice had reduced Ang-2-mRNA levels in lung tissue and isolated LECs, decreased Ang-2-plasma levels and less pulmonary Ang-2 expression after in vivo tamoxifen injection.
ISSN:1073-449X
1535-4970