A74 REGULATORY MECHANISMS OF THE MOLECULAR PATHWAYS IN FIBROSIS: Apolipoprotein A-I And Apolipoprotein E Differentially Modulate The Expression Of Extracellular Matrix Proteins By Ipf Lung Fibroblasts

Objective: To assess whether apoA-I and apoE modify the expression of extracellular matrix (ECM) proteins (fibronectin and type I collagens, COL1A1 and COL1A2) and the myofibroblast protein, a-smooth muscle actin (a-SMA), by human lung fibroblasts. [...]apoA-I (5 uM) induced a 12% increase in a-SMA...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Figueroa, D, Bui, S, Rodriguez, L, Grant, G, Nathan, S D, Levine, S J
Format: Article
Language:English
Subjects:
Apolipoproteins
Extracellular matrix
Fibroblasts
Lungs
Proteins
Pulmonary fibrosis
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Summary:Objective: To assess whether apoA-I and apoE modify the expression of extracellular matrix (ECM) proteins (fibronectin and type I collagens, COL1A1 and COL1A2) and the myofibroblast protein, a-smooth muscle actin (a-SMA), by human lung fibroblasts. [...]apoA-I (5 uM) induced a 12% increase in a-SMA expression by IPF lung fibroblasts, whereas apoE (0.5 uM) had no effect.
ISSN:1073-449X
1535-4970