C18 MECHANISMS OF AIRWAY HYPERRESPONSIVENESS AND REMODELING: Acute, Transient Modulation Of Airway Smooth Muscle Contractility By Th2 Differentiated T-Cells

Rationale: Airway smooth muscle (ASM) is believed to be hypercontractile in asthma but data from human trachealis and main bronchi ASM tissues do not show intrinsic differences compared to control ASM. Results: Our preliminary data showed that asthmatic peripheral ASM exhibits a 28% greater maximal...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Ijpma, G, Kachmar, L, Lee, S, Abd-Ali, S, Matusovsky, O, Gaudreault, V, Fixman, E, Lauzon, A-M
Format: Article
Language:English
Subjects:
Asthma
Cytokines
Flow cytometry
Rodents
Smooth muscle
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Summary:Rationale: Airway smooth muscle (ASM) is believed to be hypercontractile in asthma but data from human trachealis and main bronchi ASM tissues do not show intrinsic differences compared to control ASM. Results: Our preliminary data showed that asthmatic peripheral ASM exhibits a 28% greater maximal shortening velocity (Vmax) and an 80% greater maximal contractile stress than control. 24h incubation of trachealis muscle strips with Th2 cells showed an increase in Vmax of 25% in a control subject and 70% in a severe asthmatic as well as hypersensitivity in the MCh dose response.
ISSN:1073-449X
1535-4970