C108 GETTING INFLAMED: MARKERS OF LUNG INJURY AND REMODELLING: Brain-Derived Neurotrophic Factor Promotes Remodeling Mechanisms In Human Airway Epithelial Cells

Methods and Results: Studies used human airway epithelial cells, BEAS-2B and primary human bronchial epithelial cells (BEC). Conclusions: Similar to pro-inflammatory cytokines, TNFa and IL-13, BDNF increases expression of key mediators involved in airway remodeling including arginase 1, arginase 2,...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Britt, R, Thompson, M, Pabelick, C, Prakash, Y S
Format: Article
Language:English
Subjects:
Airway management
Asthma
Brain-derived neurotrophic factor
Cytokines
Mucous membrane
Pathogenesis
Thoracic surgery
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Summary:Methods and Results: Studies used human airway epithelial cells, BEAS-2B and primary human bronchial epithelial cells (BEC). Conclusions: Similar to pro-inflammatory cytokines, TNFa and IL-13, BDNF increases expression of key mediators involved in airway remodeling including arginase 1, arginase 2, and MMP-9 in airway epithelial cells.
ISSN:1073-449X
1535-4970