A19 THE EXTRACELLULAR MATRIX: A STICKY SITUATION: Answering A 130 Year Old Question For Asthma And Airway Fibrosis Using Optical Microscopy And Infrared Spectroscopy

In order to explore the true chemical composition of the asthmatic basement membrane, we used Fourier-transform infrared (FTIR) spectroscopy to provide quantitative information of biomolecules in tissues by assessing the nature of covalent bonds, their structure, and theirenvironment. Conclusions Th...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Mostaco-Guidolin, L, Osei, E T, Booth, S, Hackett, T-L
Format: Article
Language:English
Subjects:
Asthma
Collagen
Medical research
Microscopy
Spectrum analysis
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Summary:In order to explore the true chemical composition of the asthmatic basement membrane, we used Fourier-transform infrared (FTIR) spectroscopy to provide quantitative information of biomolecules in tissues by assessing the nature of covalent bonds, their structure, and theirenvironment. Conclusions This preliminary study indicates that within the asthmatic basement membrane fibrilar collagen cannot be detected by NLOM and FTIR methods, which assess the molecular structure.
ISSN:1073-449X
1535-4970