D18 WHO DOES WHAT IN COPD: THE CELLULAR ORIGINS: Airway Progenitor Exhaustion In Smokers With And Without Chronic Obstructive Pulmonary Disease

Airway progenitors were evaluated for numbers, self-renewal, multipotentiality (i.e. the ability to differentiate into a normal respiratory epithelium), and for their relationship to lung function. During differentiation, COPD airway progenitors produced an epithelium with increased basal and mucous...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Ghosh, M, Miller, Y E, Nakachi, I, Kwon, J B, Brantley, A E, Merrick, D T, Franklin, W A, Keith, R L, Vandivier, R W
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Health risk assessment
Pathogenesis
Online Access:Get full text
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Summary:Airway progenitors were evaluated for numbers, self-renewal, multipotentiality (i.e. the ability to differentiate into a normal respiratory epithelium), and for their relationship to lung function. During differentiation, COPD airway progenitors produced an epithelium with increased basal and mucous cells and decreased ciliated cells, mirroring the COPD phenotype.
ISSN:1073-449X
1535-4970