A106 HOST-PATHOGEN INTERACTIONS: Effects Of Neutrophil Depletion On M1/m2 Macrophage Polarization And Lethality Of Mice With Legionella Pneumophila Pneumonia

Using intracellular cytokine staining and flow cytometric analysis gated for lymphocyte, we observed that NK cells and CD8 T cells were the main sources of endogenous IFN-γ production and Gr-1 treatment decreased the number of CD8 T cell. Conclusion: The present data demonstrated that neutrophils ac...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Kusaka, Y, Kajiwara, C, Miyazaki, Y, Inase, N, Tateda, K
Format: Article
Language:English
Subjects:
Cytokines
Infections
Lungs
Neutrophils
Pneumonia
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Summary:Using intracellular cytokine staining and flow cytometric analysis gated for lymphocyte, we observed that NK cells and CD8 T cells were the main sources of endogenous IFN-γ production and Gr-1 treatment decreased the number of CD8 T cell. Conclusion: The present data demonstrated that neutrophils accumulation and depletion affected M1/M2 macrophage polarization by NK cell and CD8 T cell producing IFNγ, which were associated with disease severity and survival of mice with L. pneumophila pneumonia.
ISSN:1073-449X
1535-4970