D26 LUNG DEVELOPMENT AND BPD: Pretreatment With Dexamethasone Steroid Blunts The Effect Of Natriuretic Peptide Receptor-C (npr-C) Inhibition Of Terbutaline-Induced Surfactant Secretion In Human Lung Tissue Type Ii Cells

Atrial natriuretic peptide (ANP) and its receptors (NPR-A,C) are highly expressed in fetal sheep alveolar type II cells (ATIIs) and this expression decreases dramatically after birth; ANP itself is a surfactant secretagogue. Dexamethasone also decreased NPR-C expression in type II cells in vitro. [....

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Ryan, R M, Paintlia, M K, Newton, D A, Baatz, J E
Format: Article
Language:English
Subjects:
Lungs
Respiratory distress syndrome
Steroids
Surfactants
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Summary:Atrial natriuretic peptide (ANP) and its receptors (NPR-A,C) are highly expressed in fetal sheep alveolar type II cells (ATIIs) and this expression decreases dramatically after birth; ANP itself is a surfactant secretagogue. Dexamethasone also decreased NPR-C expression in type II cells in vitro. [...]inhibition of the NP system may be one of the mechanisms of the effect of prenatal steroids given to mothers to decrease respiratory distress syndrome (RDS) in premature infants.
ISSN:1073-449X
1535-4970