C31 BASIC AND TRANSLATIONAL STUDIES ON THE ROLE OF THE EPITHELIUM: The Role Of Notch Signaling During Airway Epithelial Cell Repair After Injury

Several signalling pathways are activated post injury that modulate epithelial regeneration and repair including; Notch signalling that regulates progenitor cell migration, proliferation and differentiation. Furthermore, Notch signalling inhibition resulted in a reduction of a5 integrin protein expr...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Iosifidis, T, Sutanto, E N, Ling, K -M, Garratt, L W, Looi, K, Kicic-Starcevich, E, Martinovich, K M, Shaw, N C, Montgomery, S T, Lannigan, F J, Knight, D, Stick, S, Kicic, A
Format: Article
Language:English
Subjects:
Asthma
Cell adhesion & migration
Gene expression
Protein expression
Proteins
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Summary:Several signalling pathways are activated post injury that modulate epithelial regeneration and repair including; Notch signalling that regulates progenitor cell migration, proliferation and differentiation. Furthermore, Notch signalling inhibition resulted in a reduction of a5 integrin protein expression in a dose-dependent manner with maximal reduction of 30% at 500 nM DAPT, potentially contributing to the observed reduction in wound repair rates.
ISSN:1073-449X
1535-4970