Cell-based Therapy for Acute Respiratory Distress Syndrome: Biology and Potential Therapeutic Value

[...]they can be stably expanded in vitro while maintaining an undifferentiated state, and it is feasible to generate sufficient quantities for clinical use and cryopreserve them before clinical use. [...]they exert multiple effects on the host immune response to injury, while maintaining or augment...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-08, Vol.196 (3), p.266
Main Authors: Laffey, John G, Matthay, Michael A
Format: Article
Language:English
Subjects:
Clinical trials
Edema
Endothelium
Immune system
Mortality
Respiratory distress syndrome
Respiratory therapy
Sepsis
Stem cells
Umbilical cord
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Summary:[...]they can be stably expanded in vitro while maintaining an undifferentiated state, and it is feasible to generate sufficient quantities for clinical use and cryopreserve them before clinical use. [...]they exert multiple effects on the host immune response to injury, while maintaining or augmenting the host response to pathogens and facilitating tissue repair. [...]current clinical studies are focused on single-dose hMSC administration via the less-invasive intravenous route, with the START (Stem Cells for Acute Respiratory Distress Syndrome) trial demonstrating safety for this approach (51). The clinical criteria are sensitive but lack specificity. [...]although the criteria are a good screening tool for ARDS, a significant proportion of patients who fulfill the clinical criteria may not actually have primarily acute lung injury.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201701-0107CP