ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES

Interleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, addin...

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Bibliographic Details
Published in:Medit͡s︡inskai͡a︡ immunologii͡a 2016-01, Vol.18 (6), p.569
Main Authors: Drutskaya, M S, Gorshkova, E A, Zhdanova, A S, K-S Atretkhany, Gogoleva, V S, Zvartsev, R V, Kruglov, A A, Nedospasov, S A
Format: Article
Language:Russian
Subjects:
Arthritis
Autoimmune diseases
Collagen
Immunoglobulins
Immunoregulation
Immunosuppressive agents
Interleukin 6
Monoclonal antibodies
Tumor necrosis factor
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Summary:Interleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, adding to a range of known biological drugs, such as, TNF blockers. Rheumatic disorders and their experimental therapy are reproducible in mice. This study revealed systemically increased levels of IL-6 in developing arthritis caused by transfer of pathogenic antibodies, as well as the effects of IL-6 neutralization by monoclonal antibodies against murine IL-6. Our results suggest a pathogenic role of the two cytokines, TNF and IL-6, in experimental arthritis induced by passive transfer of anti-collagen antibodies.
ISSN:1563-0625
2313-741X
DOI:10.15789/1563-0625-2016-6-569-574