RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-[kappa]B-IL-8 axis

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, which is a heterogeneous disease and main risk factors are associated with inflammation, family history, genetic mutations, epigenetics, and so on. Ring finger domain proteins have been reported involved in carcinogenesis,...

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Bibliographic Details
Published in:Cell death & disease 2017-08, Vol.8 (8)
Main Authors: Geng, Rong, Tan, Xin, Wu, Jiangxue, Pan, Zhizhong, Yi, Min, Shi, Wei, Liu, Ranyi, Yao, Chen, Wang, Gaoyuan, Lin, Jiaxin, Qiu, Lin, Huang, Wenlin, Chen, Shuai
Format: Article
Language:English
Subjects:
Carcinogenesis
Cell adhesion & migration
Cell growth
Cell proliferation
Colorectal cancer
Colorectal carcinoma
DNA microarrays
Epigenetics
Interleukin 8
Invasiveness
Leukocyte migration
Metastases
Metastasis
NF-κB protein
Risk factors
siRNA
Survival
Transcription
Tumors
Ubiquitin
Ubiquitin-protein ligase
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Summary:Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, which is a heterogeneous disease and main risk factors are associated with inflammation, family history, genetic mutations, epigenetics, and so on. Ring finger domain proteins have been reported involved in carcinogenesis, whereas their roles in CRC are rarely studied. Here, we reanalyzed the expression of 202 RNF family members in CRC using published microarray data from GEO database and found that RNF183 is markedly upregulated in tumor tissues. RNF183 high expression is significantly associated with tumor size (P=0.012), tumor invasive depth (P=0.004), TNM stage (P=0.01), and distant metastasis (P=0.009). CRC patients with high expression of RNF183 have poor overall survival (P
ISSN:2041-4889
DOI:10.1038/cddis.2017.400