Antidiarrheal Activity and Phytochemical Analysis of Carica papaya Fruit Extract

Treating diarrheal disease is a challenge with the emerging antimicrobial-resistant pathogens. [...]the use of traditional medicine or natural compounds is gaining importance in the antibiotic resistance era. The Minimum Inhibitory Concentration (MIC) of the Carica papaya fruit extract and the posit...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2017-07, Vol.9 (7), p.1151
Main Authors: Prabhu, Akshata Krishna, Devadas, Suganthi Martena, Lobo, Richard, Udupa, Padmanabha, Chawla, Kiran, Ballal, Mamatha
Format: Article
Language:English
Subjects:
Amino acids
Antimicrobial agents
Carbohydrates
Diabetes
Disease
E coli
Fruits
Herbal medicine
Hydrocarbons
Pathogens
Pharmaceuticals
Salmonella
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Summary:Treating diarrheal disease is a challenge with the emerging antimicrobial-resistant pathogens. [...]the use of traditional medicine or natural compounds is gaining importance in the antibiotic resistance era. The Minimum Inhibitory Concentration (MIC) of the Carica papaya fruit extract and the positive control - Ciprofloxacin (0.002-32mcg/mL; HiMedia Ltd, India) and Tetracycline (0.016-256mcg/mL; HiMedia Ltd, India) was determined for Escherichia coli (ATCC 25922) , Salmonella typhimurium (NTCC12023), Shigella dysentriae (NTCC4839) and Vibrio cholerae (NTCC4711), Aeromonas hydrophila (NTCC8049), Plesiomonas shigelloides (NTCC9722) respectively. a) Minimum Inhibitory Concentration(MIC) The MIC of the plant extracts were determined using sterile 96-well microtitre plate method. Sudhakar et al., in their study showed that C. papaya acts as a versatile plant with a good source of vitamins, antioxidants, flavonoids, polyphenols, etc [2].A study in Tamilnadu by Vijay Kumar et al., reported the antimicrobial activity of leaf of Carica papaya against the opportunistic bacterial and fungal isolates The study showed that Carica papaya can be used for the treatment of gastroenteritis, urethritis, otitis media, dengue fever, typhoid fever and wound infections [9]. [...]exploration into the mechanism of action of these phytochemical components along with their toxicity against these pathogens is essential. [...]the present study provides a scientific basis for the use of the common fruit extracts in pharmaceutics for the preparation of drugs and their possible application in gastrointestinal disorders.
ISSN:0975-1459