Inhibition of purE Gene Using Herbal Compounds to Treat Oral Diseases Caused by Oral Pathogens – An in silico Study

Trepanoma denticola is a gram negative, obligate anaerobic bacterium that dwells in a complex and diverse microbial community within the oral cavity. purE enzyme inhibits conversion of AIR to CAIR thus preventing the formation of purine nucleotide essential for energy transformation in the micro org...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2017-07, Vol.9 (7), p.1246
Main Authors: Mohanty, Swati, Ramesh, Sindhu, Priya, Vishnu V, Gayathri, R
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
E coli
Enzymes
Food
Ligands
Listeria
Oils & fats
Oral diseases
Pathogens
Proteins
Salmonella
Studies
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Summary:Trepanoma denticola is a gram negative, obligate anaerobic bacterium that dwells in a complex and diverse microbial community within the oral cavity. purE enzyme inhibits conversion of AIR to CAIR thus preventing the formation of purine nucleotide essential for energy transformation in the micro organism. WHO ( World Health Organization) defines oral health as ' A state of being free from mouth and facial pain, oral and throat cancer, oral infection and sores, periodontal diseases, tooth decay, tooth loss and other diseases and disorders that limit an individual's capacity in biting, chewing , smiling, speaking and psychosocial well being'. The ability of Treponema denticola to cause damage to the epithelial cells and human gingival fibroblasts may initiate a sequence of events that may lead to bacterial invasion of deeper layers of periodontal connective tissue as observed in humans and animal studies (1,2,3,4) . Analysis of Target active Binding Sites The active sites of the ligands and the binding sites of the target protein were analyzed using Drug Discovery Studio version 3.0.
ISSN:0975-1459