Pediatric liver transplantation for fulminant hepatic failure secondary to intentional iron overdose

Acute iron poisoning may lead to life‐threatening hepatotoxicity. We present the cases of two pediatric patients with hepatotoxicity following intentional iron ingestion that progressed rapidly to fulminant hepatic failure despite treatment with deferoxamine. Liver transplantation was lifesaving in...

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Bibliographic Details
Published in:Pediatric transplantation 2017-09, Vol.21 (6), p.n/a
Main Authors: Lai, Joanne, Chu, Jaime, Arnon, Ronen
Format: Article
Language:English
Subjects:
Adolescent
Deferoxamine
Drug Overdose - complications
Female
Ferrous Compounds - poisoning
Hepatotoxicity
Humans
Ingestion
Iron
Liver
Liver Failure, Acute - chemically induced
Liver Failure, Acute - surgery
Liver Transplantation
Liver transplants
Overdose
pediatric
Pediatrics
Poisoning
Suicide, Attempted
Toxicity
transplant
Transplantation
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Description
Summary:Acute iron poisoning may lead to life‐threatening hepatotoxicity. We present the cases of two pediatric patients with hepatotoxicity following intentional iron ingestion that progressed rapidly to fulminant hepatic failure despite treatment with deferoxamine. Liver transplantation was lifesaving in both patients. These cases emphasize the need for a high index of suspicion for iron ingestion, close monitoring for liver toxicity, and timely consideration for liver transplantation.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.12994