A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging

We present a new efficient method of incorporation of gadolinium chelates into polymeric shell surrounding liquid nanoparticles of perfluorotributylamine, which does not degrade the particles stability. The payload reaches ca. 10 5 Gd ions per nanoparticle giving large local concentration of contras...

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Bibliographic Details
Published in:BioNanoScience 2017-09, Vol.7 (3), p.456-463
Main Authors: Gervits, Lev L., Shibaev, Andrey V., Gulyaev, Mikhail V., Molchanov, Vyacheslav S., Anisimov, Nikolai V., Pirogov, Yury A., Khokhlov, Alexei R., Philippova, Olga E.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biomaterials
Biophysics
Chelates
Circuits and Systems
Engineering
Gadolinium
Magnetic fields
Magnetic resonance imaging
Nanoparticles
Nanotechnology
NMR
Nuclear magnetic resonance
Nuclei
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Summary:We present a new efficient method of incorporation of gadolinium chelates into polymeric shell surrounding liquid nanoparticles of perfluorotributylamine, which does not degrade the particles stability. The payload reaches ca. 10 5 Gd ions per nanoparticle giving large local concentration of contrast agent. The relaxivity of Gd-loaded nanoparticles estimated by magnetic resonance imaging at 7 T magnetic field is as high as 10 5 –10 6  mM −1  s −1 . These nanoparticles are promising for dual-mode imaging simultaneously on two nuclei 1 H and 19 F, thus enhancing the quality of visualization.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-017-0400-8