microRNAs and thyroid cancer: Biological and clinical significance

Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-risk lesions. mic...

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Bibliographic Details
Published in:International journal of molecular medicine 2012-11, Vol.30 (5), p.991-999
Main Authors: LEONARDI, GIULIA COSTANZA, CANDIDO, SAVERIO, CARBONE, MAURIZIO, COLAIANNI, VALERIA, GAROZZO, SEBASTIANO F, CINÀ, DIANA, LIBRA, MASSIMO
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Cell growth
Clinical significance
Gene expression
Genomes
Kinases
Metastasis
microRNA
MicroRNAs
Mutation
Proteins
RNA polymerase
Studies
Thyroid cancer
Tumors
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Summary:Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-risk lesions. microRNAs (miRNAs) are small RNA molecules with regulatory function and marked tissue specificity that modulate multiple targets belonging to several pathways. They are frequently deregulated in cancer and constitute a new class of blood-based biomarkers useful for cancer detection and prognosis definition, including thyroid cancer. In this review, the role of miRNAs in thyroid cancer development is described. The most common miRNAs detected in thyroid cancer along with their clinical significance are also discussed. Further studies aimed to detect plasma-based miRNA biomarkers in thyroid cancer patients may provide further insight into the management of thyroid cancer.
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2012.1089