Evaluation of the genetic variability of human papillomavirus type 52

Human papillomavirus (HPV) type 52 is one of the high-risk HPV types. Its variants can be classified as of Asian and European lineages, while little data of HPV 52 variants are available from China. In this study, the complete E6 and L1 genes were amplified and sequenced in 79 samples from eastern G...

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Bibliographic Details
Published in:International journal of molecular medicine 2012-09, Vol.30 (3), p.535-544
Main Authors: CHEN, QIANG, LUO, ZHAO-YUN, LIN, MIN, YANG, LIN, YANG, LI-YE, JU, GUI-ZHI
Format: Article
Language:English
Subjects:
Asian Americans
Cervical cancer
Deoxyribonucleic acid
DNA
Enzymes
Gene amplification
genetic variability
high resolution melting
Human papillomavirus
human papillomavirus type 52
Infections
multiple variants infection
Software
Studies
Womens health
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Summary:Human papillomavirus (HPV) type 52 is one of the high-risk HPV types. Its variants can be classified as of Asian and European lineages, while little data of HPV 52 variants are available from China. In this study, the complete E6 and L1 genes were amplified and sequenced in 79 samples from eastern Guangdong, China. In total, 21 variants were identified, 18 of which could be divided into Asian lineage and the other three were phylogenetically related to European lineage. No significant difference was found between the pathogenicity of these two lineage variants. Two HPV-52 lineages variants could be classified by high resolution melting (HRM) analysis. Thus, we believe that the application of HRM analysis would be useful for facilitating pathogenic comparisons between different HPV variants. In addition, we found that 6 females were infected with two types of HPV-52 variants. To our knowledge, this is the first time that this rare phenomenon is reported worldwide.
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2012.1017