miR-129-2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression

We report the emerging role of microRNA (miRNA) deregulation associated with activation of an oncogene SOX4 (a member of the SRY-related HMG-box) in esophageal carcinoma. Paired esophageal cancer and adjacent non-tumor tissues were obtained from 42 patients who underwent primary surgical resection f...

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Bibliographic Details
Published in:International journal of molecular medicine 2013-07, Vol.32 (1), p.51-58
Main Authors: KANG, MIN, LI, YUMEI, LIU, WENQI, WANG, RENSHENG, TANG, ANZHOU, HAO, HONG, LIU, ZHENGUO, OU, HESHENG
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cancer therapies
Cell culture
Cell growth
Esophageal cancer
Gene expression
Medical prognosis
Metastasis
migration
miR-129-2
proliferation
Proteins
SOX4
Studies
Transcription factors
Tumorigenesis
Tumors
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Summary:We report the emerging role of microRNA (miRNA) deregulation associated with activation of an oncogene SOX4 (a member of the SRY-related HMG-box) in esophageal carcinoma. Paired esophageal cancer and adjacent non-tumor tissues were obtained from 42 patients who underwent primary surgical resection for esophageal cancer. Experiments such as real-time PCR, western blot analysis, luciferase-reporter assay, cell proliferation and colony formation assays, in vitro migration and invasion assays, and a wound-healing assay were performed to determine the effects of miR-129-2. We found that SOX4 expression was elevated (P
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2013.1384