Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the brain

Spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) are frequently used as rat models not only of essential hypertension and stroke, but also of attention-deficit hyperactivity disorder (ADHD). Normotensive Wistar-Kyoto rats (WKY) are used as the control rats in these cases. An increa...

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Bibliographic Details
Published in:International journal of molecular medicine 2014-04, Vol.33 (4), p.887-896
Main Authors: YOSHIDA, MOMOKO, WATANABE, YUKO, YAMANISHI, KYOSUKE, YAMASHITA, AKIFUMI, YAMAMOTO, HIDEYUKI, OKUZAKI, DAISUKE, SHIMADA, KAZUNORI, NOJIMA, HIROSHI, YASUNAGA, TERUO, OKAMURA, HARUKI, MATSUNAGA, HISATO, YAMANISHI, HIROMICHI
Format: Article
Language:English
Subjects:
Age
Annotations
Antigens
Apoptosis
Attention Deficit Hyperactivity Disorder
Brain
Cardiovascular system
Care and treatment
Data analysis
Development and progression
Gene expression
gene expression profiles
Genomes
Hypertension
Laboratory animals
Metabolism
microarray
Nervous system
normotensive Wistar-Kyoto rats
Patient outcomes
Proteins
Risk factors
Rodents
spontaneously hypertensive rats
stroke-prone
Studies
Systems development
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Summary:Spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) are frequently used as rat models not only of essential hypertension and stroke, but also of attention-deficit hyperactivity disorder (ADHD). Normotensive Wistar-Kyoto rats (WKY) are used as the control rats in these cases. An increasing number of studies has demonstrated the critical role of the central nervous system in the development and maintenance of hypertension. In a previous study, we analyzed the gene expression profiles in the adrenal glands of SHR. Thus, in this study, we analyzed gene expression profiles in the brains of SHR in order to identify the genes responsible for causing hypertension and stroke, as well as those involved in ADHD. Using genome-wide microarray technology, we examined the gene expression profiles in the brains of 3 rat strains (SHR, SHRSP and WKY) when the rats were 3 and 6 weeks of age, a period in which the rats are considered to be in a pre-hypertensive state. Gene expression profiles in the brain were compared between SHR and WKY, and between SHRSP and SHR. A total of 179 genes showing a >4- or
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2014.1631