Synthesis and Evaluation of Isoflavones as Potential Anti-inflammatory Inhibitors

A series of isoflavones was synthesized in high yields from 3-iodochromones via the Suzuki–Miyaura reaction. Selected isoflavones were then evaluated for potential anti-inflammatory and/or HIV reverse transcriptase inhibitory properties. Only 3-(4 ′ -methoxyphenyl)-4H-chromen-4-one 4b , 3-(4 ′ -chlo...

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Bibliographic Details
Published in:Arabian journal for science and engineering (2011) 2017-10, Vol.42 (10), p.4263-4271
Main Authors: Ramaite, Isaiah D. I., Maluleke, Musa D., Mnyakeni-Moleele, Simon S.
Format: Article
Language:English
Subjects:
Chemical synthesis
Engineering
Humanities and Social Sciences
Isoflavones
multidisciplinary
Research Article - Special Issue - Functional Materials - Chemistry
Science
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Summary:A series of isoflavones was synthesized in high yields from 3-iodochromones via the Suzuki–Miyaura reaction. Selected isoflavones were then evaluated for potential anti-inflammatory and/or HIV reverse transcriptase inhibitory properties. Only 3-(4 ′ -methoxyphenyl)-4H-chromen-4-one 4b , 3-(4 ′ -chlorophenyl)-4H-chromen-4-one 4c and 3-(4 ′ -bromophenyl)-4H-chromen-4-one 4d showed dose-dependent attenuation of LPS-induced nitrate production indicating potential anti-inflammatory activity. NO production was 1.21, 1.43 and 1.43  μ M , respectively, even at the highest concentration of 50  μ M tested. However, relative to the positive control these activities are weak. None of the screened compounds was found to exhibit significant reverse transcriptase inhibition at the highest concentration of 50  μ M tested.
ISSN:2193-567X
1319-8025
2191-4281
DOI:10.1007/s13369-017-2614-z