Cytogenetical analysis in blood lymphocytes of cigarette smokers in Tiruchirappalli district, Tamil Nadu, India

Tobacco smoke causes serious health ill effects to human population. Cancer and cardiovascular diseases are more common in smoking subjects. The present study is focused about the genetical changes in smoking subjects based on their age and pack years. Based on a survey report, 160 subjects are sele...

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Bibliographic Details
Published in:The Egyptian journal of medical human genetics 2017-04, Vol.18 (2), p.147-152
Main Authors: Christobher, S., Periyasamy, M., Syed Mohamed, H.E., Sadiq Bukhari, A., Karthickkumar, Alagamuthu, Balachandar, Vellingiri
Format: Article
Language:English
Subjects:
Age
Biomarkers
Blood
Cancer
Cardiovascular diseases
Cell cycle
Chromatid aberration
Chromosomes
Cigarettes
Comet assay
Deoxyribonucleic acid
DNA
Lymphocytes
Micronuclei
Mutagenesis
Occupational health
Smoke
Smoking
Surveillance
Tobacco
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Summary:Tobacco smoke causes serious health ill effects to human population. Cancer and cardiovascular diseases are more common in smoking subjects. The present study is focused about the genetical changes in smoking subjects based on their age and pack years. Based on a survey report, 160 subjects are selected from Tiruchirappalli district, Tamil Nadu, India. Venous blood and buccal smear samples are collected from each subject. Increased CA is observed in heavy smokers compared to light and non smokers which is 8.90±2.58, 4.58±2.36 and 4.31±1.17, respectively. Both medium and light smokers showed significantly increased CA frequencies than control. Comet assay showed increased percentage of abnormalities in smokers (light, medium and heavy) than non-smokers. The frequencies of MN in buccal epithelial and blood lymphocytes are high in smokers; particularly heavy smoker group showed significantly increased results. Among them, the lymphocytic cells showed high MN frequency.
ISSN:1110-8630
2090-2441
DOI:10.1016/j.ejmhg.2016.05.003