Solubility and Dissolution Thermodynamic Data of Cefpiramide in Pure Solvents and Binary Solvents

The solubility of cefpiramide in five pure solvents (water, ethanol, 1-propanol, 2-propanol, and 1-butanol) and two binary solvent systems (water + ethanol or water + 2-propanol) was measured by a steady-state method, from 278.2 to 303.2 K, under atmospheric pressure. The initial mole fraction of al...

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Bibliographic Details
Published in:Journal of solution chemistry 2017-08, Vol.46 (8), p.1556-1574
Main Authors: Tang, Fengxiang, Wu, Shan, Zhao, Suying
Format: Article
Language:English
Subjects:
Alcohol
Alcohols
Atmospheric pressure
Binary mixtures
Butanol
Chemistry
Chemistry and Materials Science
Computer simulation
Condensed Matter Physics
Dissolution
Endothermic reactions
Ethanol
Geochemistry
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Oceanography
Physical Chemistry
Solubility
Solvents
Thermodynamic properties
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Summary:The solubility of cefpiramide in five pure solvents (water, ethanol, 1-propanol, 2-propanol, and 1-butanol) and two binary solvent systems (water + ethanol or water + 2-propanol) was measured by a steady-state method, from 278.2 to 303.2 K, under atmospheric pressure. The initial mole fraction of alcohol (ethanol or 2-propanol) in the binary systems ranged from 0 to 1. It is found that the solubility increases with increasing temperature in the experimental range and shows a quasi-S-shaped curve with the increase of the initial mole fraction of alcohol. The modified Apelblat equation was used to simulate the solubility data, and gives a maximum mean relative deviation (MRD) of 0.47% for the single solvent systems, and a maximum MRD of 1.03 and 1.15% for the ethanol + water and 2-propanol + water systems, respectively. The combined model of the Jouyban–Acree and modified Apelblat equations, both temperature-dependent and solvent-composition-dependent, was simplified to correlate the solubility data of binary solvent mixtures in the initial mole fraction range of alcohol from 0 to 0.9, and gives a MRD of 9.83 and 6.49% for the ethanol +water and 2-propanol + water systems, respectively. The dissolution thermodynamic properties in the pure solvents and two binary mixtures were calculated based on the van’t Hoff equation. The calculation results indicate that the dissolution process of cefpiramide is endothermic in the pure solvents, and entropically driven in the four alcohols but not in water. The dissolution process is endothermic in the two binary mixtures.
ISSN:0095-9782
1572-8927
DOI:10.1007/s10953-017-0664-1