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Orbital recurrence of uveal melanoma after 45 years from enucleation

Purpose A 52‐year‐old woman who had undergone enucleation of the left eye at the age of 7 years for posterior uveal melanoma, had no further problems until 45 years later, when she developed a multifocal malignancy of the ipsilateral orbit. Methods Case report. Results MRI documented the presence of...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2017-09, Vol.95 (S259), p.n/a
Main Authors: Hadjistilianou, T., Galluzzi, P., Toti, P., Menicacci, F., Menicacci, C., Daini, R., Pica, A., Zografos, L.
Format: Article
Language:English
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Summary:Purpose A 52‐year‐old woman who had undergone enucleation of the left eye at the age of 7 years for posterior uveal melanoma, had no further problems until 45 years later, when she developed a multifocal malignancy of the ipsilateral orbit. Methods Case report. Results MRI documented the presence of nodular multiple masses in the anophthalmic socket suggesting possible metastatic disease. Hepatic examination and ultrasound evaluation, CT scan of the thorax and bone scintigraphy excluded other sites of metastatic lesions. She underwent excissional of the 3 distinct tumors, 2 inferiorly and one superiorly in the anophthalmic socket. After surgery she received proton beem radiotherapy in the anopthalmic socket for a total of 4.600rads. Histopathology documented malignant melanoma of the orbit characterized by epitheliod cells. Conclusions The long interval between recognition of the primary tumor and enucleation and the appearance of clinically manifest metastatic disease in the ipsilateral orbit is the longest reported in the literature to date. A similar case of metastatic choroidal melanoma to the contralateral orbit 40 years after enucleation has been reported by Coupland (1996).
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2017.04144