Synthesis, characterization and hemolysis studies of Zn^sub (1-x)^Ca^sub x^Fe^sub 2^O^sub 4^ ferrites synthesized by sol-gel for hyperthermia treatment applications

The synthesis of Zn(1-x)CaxFe2O4 nanoparticles, x=0, 0.25, 0.50, 0.75 and 1.0, was performed by sol-gel method followed by a heat treatment at 400 °C for 30 min. These ferrites showed nanometric sizes and nearly superparamagnetic behavior. The Zn0.50Ca0.50Fe2O4 and CaFe2O4 ferrites presented a size...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2017-04, Vol.427, p.241
Main Authors: Jasso-Terán, Rosario Argentina, Cortés-Hernández, Dora Alicia, Sánchez-Fuentes, Héctor Javier, Reyes-Rodríguez, Pamela Yajaira, de-León-Prado, Laura Elena, Escobedo-Bocardo, José Concepción, Almanza-Robles, José Manuel
Format: Article
Language:English
Subjects:
Ferrites
Heat treating
Heat treatment
Hemolysis
Hyperthermia
Nanoparticles
Sol-gel processes
Synthesis
Zinc
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Summary:The synthesis of Zn(1-x)CaxFe2O4 nanoparticles, x=0, 0.25, 0.50, 0.75 and 1.0, was performed by sol-gel method followed by a heat treatment at 400 °C for 30 min. These ferrites showed nanometric sizes and nearly superparamagnetic behavior. The Zn0.50Ca0.50Fe2O4 and CaFe2O4 ferrites presented a size within the range of 12-14 nm and appropriate heating ability for hyperthermia applications. Hemolysis testing demonstrated that Zn0.50Ca0.50Fe2O4 ferrite was not cytotoxic when using 10 mg of ferrite/mL of solution. According to the results obtained, Zn0.50Ca0.50Fe2O4 is a potential material for cancer treatment by magnetic hyperthermia therapy.
ISSN:0304-8853
1873-4766