Orexin system increases energy expenditure by brown adipose tissue activity

Furthermore, substantial evidences show that BAT activation leads to increased thermogenesis. [...]the regulation of the SNS tone provides a complex mechanism able to specifically coordinate the function of the organs involved in energy homeostasis. In this experiment, an ICV injection of orexin A i...

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Bibliographic Details
Published in:National journal of physiology, pharmacy and pharmacology pharmacy and pharmacology, 2017, Vol.7 (7), p.1
Main Authors: Messina, Antonietta, Monda, Vincenzo, Villano, Ines, Valenzano, Anna, Salerno, Monica, Tafuri, Domenico, Chieffi, Sergio, Sullo, Alessio, Cibelli, Giuseppe, Monda, Marcellino, Messina, Giovanni
Format: Article
Language:English
Subjects:
Adipocytes
Body fat
Cold
Cytokines
Homeostasis
Hormone replacement therapy
Lipids
Mammals
Metabolic syndrome
Nervous system
Neuropeptides
Obesity
Oxidative stress
Proteins
Rodents
Thermogenesis
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Summary:Furthermore, substantial evidences show that BAT activation leads to increased thermogenesis. [...]the regulation of the SNS tone provides a complex mechanism able to specifically coordinate the function of the organs involved in energy homeostasis. In this experiment, an ICV injection of orexin A induces an increase in the sympathetic activity and in the TIBAT independently of food ingestion, which is reduced in the rats with a delayed presentation of food. [...]the effects of orexin A on body temperature are predominant with respect to food intake. [21] PERSPECTIVES BAT is now accepted as a regulatory site of (EE) and body fatness in adult humans. [...]other studies have indicated that BAT has roles in the regulation of glucose and lipid metabolism through somebody fat-independent mechanisms. [...]BAT is a promising target for combating not only obesity but also some related metabolic diseases.
ISSN:2320-4672
2231-3206
DOI:10.5455/njppp.2017.7.0205422042017